

The complete search strategies are available on request. The following search terms were used: craniofacial, craniosynostosis combined with: genetics, hydrocephalus, Chiari, cerebral pressure, otitis, hearing, vision, psychology, anesthesia, complications, infection, development, growth, maxilla, mandible, distraction, osteotomy, Fort, midface, RED, halo, monobloc, facial bipartition, median fasciotomy, hypertelorism. Regarding all basic questions, patient categories were defined in a uniform way. Searches were performed until 1 December 2009 and articles available as “Epub ahead of publication” at that date were included as well. This resulted for several basic questions in additional articles.Ĭare for children with craniosynostosis was introduced in the late 1960 s, and consequently the English literature from those years onwards was included. In addition, articles were extracted from reference lists of relevant literature.

Searches were limited to the Dutch, English and French languages. Existing guidelines were specifically searched for in online accessible (international and national guideline clearinghouses). Relevant articles were identified using systematic searches in Medline, Embase, and the Cochrane Library. The content of this guideline is based on evidence from published scientific research. Method Employed by the Working Group Procedure in 2010
